
A complete three-step A.G.E. regimen lifting serum, corrective cream, and eye treatment, targeting wrinkles, laxity, and dark circles caused by glycation and collagen decline.
SkinCeuticals A.G.E. Skin Age Defying Set
This three-piece set brings together SkinCeuticals' full A.G.E. anti-glycation regimen in one purchase. Glycation occurs when sugar molecules bind to collagen fibres, weakening the skin's support structure and accelerating visible aging — wrinkles, sagging, and loss of definition. Each product in this set targets a different zone with the same underlying science, built on more than fifteen years of SkinCeuticals glycation research.
Use the Ultra Serum to visibly lift and sculpt the lower face and neck, layer A.G.E. Interrupter Advanced over the face, neck, and chest to correct wrinkles and laxity, then finish with A.G.E. Advanced Eye for crow's feet, puffiness, and dark circles. Together, the three cover the areas most affected by collagen decline in a single coordinated routine.
- A.G.E. Interrupter Ultra Serum — 30 ml / 1 fl oz
- A.G.E. Interrupter Advanced — 48 ml / 1.7 oz
- A.G.E. Advanced Eye — 15 ml / 0.5 oz
- Visibly tightens four key facial areas: forehead, cheeks, jawline, and neck
- Clinically proven to visibly improve wrinkles in five facial zones commonly targeted by aesthetic procedures
- Targets crow's feet, under-eye puffiness, and dark circles in the delicate eye area
- Layered actives across all three formulas: 34.6% Flavo-Proxylane in the serum, 18% concentrated Proxylane in the cream, and 7.15% Proxylane plus 3% Matrixyl 3000 in the eye treatment
- Tested on all skin types and tones; the Ultra Serum is also physician-tested on GLP-1 patients Exclusive Beauty Club
- Can be used alone or alongside in-office lifting ultrasound treatments
- Suitable for both AM and PM routines
Ultra Serum: At 4 weeks, skin appears 19% smoother and 14% more radiant. At 12 weeks, up to 18% more visible lift, up to 16% reduction in wrinkles, and up to 54% improvement in smoothness across the forehead, cheeks, jawline, and neck. A single use delivers 73% more moisture within one hour and a strengthened skin barrier.
A.G.E. Interrupter Advanced: After twelve weeks of use, participants showed a 14% improvement in overall facial lines, across crow's feet, forehead wrinkles, nasolabial folds, marionette lines, and glabellar lines.
A.G.E. Advanced Eye: Addresses ten visible signs of eye-area aging: crepiness, crow's feet, dark circles, elasticity, firmness, puffiness, radiance, smoothness, tone, and under-eye wrinkles.
Ultra Serum protocol: clinical testing of 76 non-GLP-1 subjects over 12 weeks; average results across all subjects were +7.6% lifting, −7.6% global wrinkles, and +40% smoothness.
- A.G.E. Interrupter Ultra Serum: Once or twice daily, dispense one dropper into the palm and dab onto forehead, cheeks, chin, and neck, then blend into skin.
- A.G.E. Interrupter Advanced: Twice daily, massage a thin, even layer over the entire face, neck, and chest.
- A.G.E. Advanced Eye: Twice daily, apply under the eyes following the natural curve of the cheekbone and browbone. Do not apply directly to the eyelids.
In the morning, follow with a broad-spectrum sunscreen. If using a retinol product, apply the Ultra Serum afterward in the evening.
Ultra Serum: 34.6% Flavo-Proxylane, Cassia Alata extract, Rhamnose, and Gentiana Lutea root extract to maximize lifting and sculpting.
Interrupter Advanced: 18% concentrated Proxylane, 4.25% wild fruit flavonoid blend of blueberry and pomegranate extracts, and 0.1% glycyrrhetinic acid.
Advanced Eye: 7.15% concentrated Proxylane, 4.25% wild fruit flavonoids, 3% Matrixyl 3000, 0.2% glycyrrhetinic acid, 0.5% caffeine, and 0.8% inclusive optical effects.
- Dry
- Normal
- Combination
- Oily
- Sensitive
- Aging
















